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The study protocol was approved by the Institutional Ethics Committee for Biomedical and Healthcare Research

Use caution when prescribing CONTRAVE to patients with an elevated risk of seizure, including: history of head trauma or prior seizure, severe stroke, arteriovenous malformation, central nervous system tumor or infection, or metabolic disorders (eg, hypoglycemia, hyponatremia, severe hepatic impairment, and hypoxia)

The protective and inhibitive effects of antioxidants on protein modification, lipid peroxidation, and DNA damage due to ROS have also been highlighted

Plan for a transition: If stopping the medication, work with your doctor to ease off gradually and prevent weight regain